Breast Cancer Microenvironment Cross Talk through Extracellular Vesicle RNAs

Exploration of extracellular communication has been at the forefront research efforts in recent years. However, mechanisms cell-to-cell complex tissues are poorly understood. What is clear that cells do not exist isolation, they constantly interacting and communicating with immediate vicinity a distance. Intercellular by release small vesicles, called exosomes, loaded RNAs one mechanism which communicate. In years, shown class can play major role pathogenesis breast cancer. Specifically, exosomes have demonstrated to promoting primary cancer development, invasion, metastasis, chemotherapeutic resistance. This review summarizes what known about exosome-mediated transfer among microenvironment discusses outstanding questions potential for new therapeutic intervention targeted these interactions. 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